ライフサイエンスコーパス: adaptor

1 capturing beta-catenin via the Legless/BCL9 adaptor.

2 complex formation with dynactin and a cargo adaptor.

3 together with MOB1 as an important signaling adaptor.

4 mic domain for binding to actin cytoskeleton adaptors.

5 n-ligase, recruited by alpha-arrestin-family adaptors.

6 that the surround contours are all potential adaptors.

7 the SLAM-associated protein (SAP) family of adaptors.

8 activation molecule-associated protein (SAP) adaptors.

9 demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-established PP1-in

10 ivation results in the interaction of IL-17R adaptor Act1 with NICD1, followed by the translocation o

11 n and cargo binding that ensures that robust adaptor activity is maintained when high amounts of subs

12 er between BORC and late endosomal/lysosomal adaptor and mitogen activated protein kinase and mechani

13 y conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical as

14 lass I myosins, the dual-GEF Trio, and other adaptors and signaling molecules.

15 of oligos avoids the necessity of preparing adaptors and the problems associated with inter-adaptor

16 The isolated oligonucleotides are ligated to adaptors, and after damage-specific immunoprecipitation,

17 involves a vast array of enzymes, signaling adaptors, and cytoskeletal components.

18 ptors and the problems associated with inter-adaptor annealing/ligation.

19 the medium subunit (micro1) of the clathrin adaptor AP-1 as a top hit.

20 tant lacking binding sites for the endocytic adaptor AP-2 proteins fails to rescue endocytosis, indic

21 we show that PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not c

22 14-3-3 adaptors are hub proteins that are attractive targets to

23 strand) oligos rather than (double-stranded) adaptors are ligated.

24 d relies on the arrestin-related trafficking adaptor (ART)-Rsp5 ubiquitin ligase adaptor network in y

25 ligase Rsp5 and arrestin-related trafficking adaptors (ARTs).

26 ction properties of the p24 and ERV-29 cargo adaptors, as well as their role in cellulase enzyme traf

27 sensors trigger assembly of the inflammasome adaptor ASC into specks, large signaling platforms consi

28 y requires the PYRIN domain (PYD)-containing adaptor ASC, and depends on PYD-PYD interactions.

29 ng muscle atrophy, as the cullin-1 substrate adaptor atrogin-1 is among the most well-characterized m

30 of the viral late gene mRNAs by acting as an adaptor between the viral mRNAs and the cellular mRNA nu

31 s late viral gene expression by acting as an adaptor between viral mRNAs and the cellular nuclear exp

32 the accessory complex dynactin and the cargo adaptor Bicaudal-D2 (BICD2).

33 These adaptors bind cargo via a C-terminal mu-homology domain

34 We find that only the combination of adaptor binding and cytoskeletal force provides ultrasen

35 fferences in interactions with intracellular adaptors but do not predict cellular adhesiveness for im

36 Combined targeting of UBAP1 and TLR adaptors by PumA impedes both cytokine and TLR receptor

37 unts of substrate must be delivered and that adaptors can be eliminated when their tasks have been co

38 The distribution of adaptors changes in space and time and may segregate to

39 We now report that the Salmonella adaptor ClpS binds to the N terminus of the regulatory p

40 In bacteria, the adaptor ClpS mediates proteolysis by delivering substrat

41 An exosome adaptor complex called NEXT (nuclear exosome targeting)

42 ly on a single Y-171 site for the binding to adaptor complex GRB-2-SKAP1.

43 HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/

44 Exomer is an adaptor complex required for the direct transport of a s

45 CCMs arise from the loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 s

46 f the abundance and activity of these ligase-adaptor complexes is critical for main-tenance of optima

47 by the cytoskeleton, across ligand-integrin-adaptor complexes.

48 eeds and temporal phases between the central adaptor contour and the surround texture and measured fo

49 Shape aftereffects are suppressed when the adaptor contour is surrounded by a texture of similarly-

50 in which the SCCRO, substrate, and substrate adaptors cooperatively provide tight control of neddylat

51 petitive interruption of dynein-Snapin motor-adaptor coupling, thus immobilizing them in distal axons

52 P2 regulates its interaction with the Reelin adaptor Dab1 and this association is required for CLASP2

53 with the VLDLR and its downstream signaling adaptor Dab1 to facilitate Reelin signaling.

54 ivates Syk without the help of the signaling adaptor Dap12 or FcRgamma.

55 strate that tango7, not the canonical Apaf-1-adaptor dark, regulates dronc activity at the cortex; in

56 r work points to an optimization of inherent adaptor degradation and cargo binding that ensures that

57 e means to spare specific substrates from an adaptor-dependent protease.

58 e association of receptor with the signaling adaptor depends on a network of polar and aromatic resid

59 no acid positions in receptors, kinases, and adaptors determine their pathway specificity, assigning

60 Third, distinct adaptors downstream of Tolls can drive either apoptosis

61 vivo Gata6 stimulates EDA-receptor signaling adaptor Edaradd level and NF-kappaB pathway activation,

62 show that the C-terminus downstream of their adaptor elements is crucial for Wnt responses.

63 tidylinositol 3-kinase (BCAP) is a signaling adaptor expressed in mature hematopoietic cells, includi

64 ric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(

65 ila In addition, the CLAMP (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc fi

66 B-cell adaptor for phosphatidylinositol 3-kinase (BCAP) is a si

67 rocess that requires the multimodular B-cell adaptor for phosphoinositide 3-kinase (BCAP).

68 8 (MyD88), which is the only known signaling adaptor for TLR7, suggesting that a noncanonical mechani

69 primary response gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 r

70 CBH-1 and CBH-2, depend on distinct ER cargo adaptors for efficient exit from the ER.

71 late protein stability as substrate-specific adaptors for ubiquitination, have been implicated in sar

72 se it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it

73 MYO6+ and its adaptor GAIP interacting protein, C terminus (GIPC) accu

74 t roles in recruitment of two major clathrin adaptors, Gga (Golgi-localized, gamma-adaptin ear homolo

75 We show that the adaptor, GGA1, and retromer are essential to mediate rap

76 TOP-PCR adopts homogeneous "half adaptor" (HA), generated by annealing P oligo (carrying

77 ion of Stimulator of interferon genes, a key adaptor in double-stranded DNA-sensing pathway, followed

78 le for this viral Sm-class RNA as a microRNA adaptor in the regulation of gene expression that follow

79 his shows that BOP proteins act as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase comple

80 uniscins are a conserved family of endocytic adaptors, including Syp1 in budding yeast and its mammal

81 They also reveal a novel SAP adaptor-independent function for a SLAM receptor.

82 ting MyD88- and Toll/IL-1R domain-containing adaptor inducing IFN-beta-dependent pathways.

83 icated that the Toll/IL-1R domain-containing adaptor inducing IFN-beta/ TNFR-associated factor 3 path

84 ase receptor (PKR), or TIR domain-containing adaptor inducing interferon beta (TRIF) signaling or an

85 In this model, the TIR-domain-containing adaptor-inducing interferon-beta (TRIF) was a central me

86 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-gamma (TRIF), factors critic

87 a membrane proteins, independently of signal-adaptor interactions.

88 Conservation of Spindly-like motifs in adaptors involved in intracellular transport suggests a

89 d that the ability of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with

90 We show that Spindly, a dynein adaptor, is related to BicD2 and binds RZZ directly in a

91 iates homodimerization and recruits cellular adaptors, is dispensable during ER-to-cytosol transport

92 The Cul3 adaptor KLHL21 mediates the effects of SCCRO on abscissi

93 ter damage-specific immunoprecipitation, the adaptor-ligated oligonucleotides are converted to dsDNA

94 Using an optimized adaptor ligation assay, we found that most T. brucei tel

95 MyD88 adaptor-like (MAL) is a critical protein in innate immun

96 h the Fab fragment of an antibody acts as an adaptor, linking a human protein insert with antigen-bin

97 ncomitant interaction with the mitochondrial adaptor MAVS.

98 e antiviral innate immunity dependent on the adaptors MAVS and STING.

99 The adaptor MecA activates ClpC by targeting substrates and

100 Moreover, nanopores with internal protein adaptors might find further practical applications in mu

101 f the three Hippo kinases with the signaling adaptor MOB1 and show how they differently affect develo

102 ts (TOG and RNA) are modulated by a bivalent adaptor molecule (hnRNP A2).

103 Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates

104 (Q204L) did not reverse Rap1-GTP-interacting adaptor molecule (RIAM)-dependent increases in cell adhe

105 ta (4G8), microglia (ionized calcium binding adaptor molecule 1), astrocytes (glial fibrillary acidic

106 s indicate that PGC1alpha represents a novel adaptor molecule capable of recruiting the necessary tra

107 esults indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA viru

108 ivator 1alpha (PGC1alpha) serves as a unique adaptor molecule for the recruitment of additional coact

109 alphaSNAP, the adaptor molecule for the SNARE-priming enzyme N-ethylmal

110 MyD88 is the main adaptor molecule for TLR and IL-1R family members.

111 The mitochondrial adaptor molecule MAVS plays critical roles in coordinati

112 ges by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 ma

113 mechanism, we investigated the role of a key adaptor molecule SQSTM1/p62.

114 This stimulation leads to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain

115 domain protein 2 (Fhl2) is an intracellular adaptor molecule with a high protein-protein interaction

116 e peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death do

117 ing immunoreceptors associate with signaling adaptor molecules like FcepsilonR1gamma or CD247.

118 g is negatively regulated by beta-arrestins, adaptor molecules that also activate different intracell

119 ng CD64 and FcepsilonR1alpha, with signaling adaptor molecules, and we confirm experimentally that eq

120 Because adaptors must bind their cognate protease, all adaptors

121 thway that is dependent on the TLR signaling adaptor MyD88 and its downstream kinase IL-1R-associated

122 on, KSHV upregulated expression of TLR4, its adaptor MyD88, and coreceptors CD14 and MD2.

123 c deletion of the IL-1R and IL-36R signaling adaptor Myd88.

124 proteasome, the ubiquitin-binding autophagy adaptor NBR1, the autophagy protein LC3, and the lysosom

125 fficking adaptor (ART)-Rsp5 ubiquitin ligase adaptor network in yeast.

126 plasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contributes to PG enlargement by regulating

127 d that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiq

128 yl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic response in fission ye

129 en previously shown to require the transport adaptor ODA16, as well as the intraflagellar transport (

130 ram's tumour-suppressing effects as NPL4, an adaptor of p97 (also known as VCP) segregase, which is e

131 uted system and in vivo studies to show that adaptors of the ClpXP protease are readily degraded but

132 Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex.

133 domain, suggesting that GDU1 functions as an adaptor or coactivator of amino acid exporter(s).

134 so serves as the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 s

135 g establishing a deficiency in the signaling adaptor p66Shc in CLL cells, we undertook to identify un

136 ycle barcoding PCR step followed directly by adaptor PCR to generate the library and then bead purifi

137 AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein

138 TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling cascade

139 ical for interaction with the mu1 subunit of adaptor protein 1 and the major histocompatibility compl

140 tions create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold p

141 Interaction of T-bet with the adaptor protein 14-3-3z in the cytosol of CD8(+) T cells

142 pid down-regulation of CD4 via the endocytic adaptor protein 2 (AP-2) complex, a process linked to en

143 Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathr

144 When anchorage is disrupted, both the adaptor Protein 4.1B and the cytoskeleton protein betaII

145 sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulate

146 transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of an

147 ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in

148 rotein 3 (NLRP3) inflammasome to recruit the adaptor protein apoptosis-associated speck-like protein

149 CD2AP in inflamed vessels, identifying this adaptor protein as a potential therapeutic target.

150 ulation of caspase-1 activation requires the adaptor protein ASC (apoptosis-associated speck-like pro

151 ces for binding other regulators, either the adaptor protein Bicaudal-D2 (BicD2) or the multifunction

152 Second, fusion kinase inhibition shifted adaptor protein binding from the fusion oncoprotein to E

153 ing through these receptors converged on the adaptor protein CARD9, a component of the CARD9-Bcl10-MA

154 The adaptor protein CIN85 is a partner of Cbl that augments

155 iated with phosphorylation of the checkpoint adaptor protein Claspin and activation of the Chk1 effec

156 we explore the role of AP-2, a key endocytic adaptor protein complex, in the development of rat hippo

157 These findings show that 14-3-3 adaptor protein complexes are druggable targets and iden

158 Unexpectedly, the periplasmic adaptor protein CusB is a key metal-sensing element that

159 Loss of the adaptor protein cyclin-dependent kinase regulatory subun

160 this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity.

161 e endocytosed in signal-sending cells by the adaptor protein Epsin.

162 C4 and its H443P mutant are dependent on the adaptor protein FADD.

163 We propose that Pet309 acts as an adaptor protein for Mss116 action on the COX1 mRNA 5-UTR

164 rial antiviral-signaling protein (MAVS), the adaptor protein for RIG-I like receptor in regulating ho

165 rial antiviral signaling protein (MAVS), the adaptor protein for RIG-I-like receptor in regulating ho

166 HO-2 was also found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and the

167 pproach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner

168 ains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycli

169 rt the high-resolution structure of the tail adaptor protein gp7 from phage Sf6.

170 nce that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for ARM within adult

171 Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn and signal transduc

172 CABIT domain of Themis and indirectly to the adaptor protein Grb2, with the latter interaction enabli

173 h factor receptor (EGFR) and the cytoplasmic adaptor protein growth factor receptor-bound protein 2 (

174 Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is reg

175 PGRP-LE, which through interaction with the adaptor protein Imd leads to activation of the NF-kappaB

176 s, including CRKLCRKL encodes a src-homology adaptor protein implicated in mediating tyrosine kinase

177 ide insight into the mechanistic role of the adaptor protein in mediating the sequential assembly of

178 r cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEA

179 nterfering with a putative synaptic tag, the adaptor protein KIBRA, which protects the atypical PKM f

180 The integrin-activating adaptor protein kindlin-2 plays a central role for cell

181 erate intracellular signals, the immune cell adaptor protein linker for the activation of T cells (LA

182 egulate JAK2 stability and signaling via the adaptor protein LNK/SH2B3.

183 Here, we present the structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di

184 ly promotes Drp1 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff).

185 One autophagic adaptor protein not previously identified in sIBM was FY

186 the regulatory dominance of the melanophilin adaptor protein over its associated motor and offer an u

187 It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of E

188 tigated whether epigenetic regulation of the adaptor protein p66(Shc), a key driver of mitochondrial

189 ouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysf

190 ranches of the pathway, in that mTORC1 (with adaptor protein Raptor) is the main complex mediating th

191 Spata2 (spermatogenesis-associated 2) is an adaptor protein recruited into the TNF-RSC to modulate t

192 lar targets other than TIR domain-containing adaptor protein remain unclear.

193 and function of islets, whereas mTORC2 (with adaptor protein Rictor) impacts islet mass and architect

194 ted the possibility that the phosphotyrosine adaptor protein ShcA regulates nephrin turnover.

195 The adaptor protein SLP-76 is recruited to the phosphorylate

196 l the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zw

197 The adaptor protein Src homology 2 domain-containing leukocy

198 econd messenger that binds and activates the adaptor protein STING to induce type I interferons (IFNs

199 Here, we show that the adaptor protein TAX1BP1 functions as a negative regulato

200 lex virus 1 (HSV-1) interacts with CIN85, an adaptor protein that augments Cbl functions.

201 of multiple proteins, among which is a tail adaptor protein that connects the portal protein to the

202 CusB is an adaptor protein that connects the two membrane proteins

203 n receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 recep

204 p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS pr

205 f wild-type two-pronged binding of the UBXD1 adaptor protein that is impaired in disease; this underl

206 ation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and in

207 iated factor 2 (TRAF2) is a second messenger adaptor protein that plays an essential role in propagat

208 The adaptor protein TNF receptor associated factor (TRAF) 3

209 r the tail nozzle only after the assembly of adaptor protein to the portal.

210 The adaptor protein TRAF6 has a central function in Toll-lik

211 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-domain-containing adapter-indu

212 screenings, we report that the mitochondrial adaptor protein tripartite motif (TRIM)14 provides a doc

213 -like protein necroptotic signaling with the adaptor protein tumor necrosis factor receptor-associate

214 ion and phagocytosis through coupling to the adaptor protein TYRO protein-tyrosine kinase-binding pro

215 Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions.

216 riasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that coup

217 n 2) and the isolated PTB domain of Shc (SHC adaptor protein) to the EGF receptor.

218 ssays showed that suppression of AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting

219 oll-interleukin 1 receptor domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-asso

220 is negatively regulated by an actin-binding adaptor protein, i.e., CD2AP, to allow a balanced and sp

221 However, since CusB is an adaptor protein, its role in operating this system is si

222 ), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, i

223 via its receptor roundabout4 (Robo4) and the adaptor protein, Paxillin were involved in reducing BBB

224 MYO6 is present on peripheral adaptor protein, phosphotyrosine interacting with PH dom

225 requires palmitoylation for interacting with adaptor protein-2 (AP-2) and AP-3, respectively, for tra

226 al cord slices and that it is carried out by adaptor protein-2 (AP-2) via clathrin-mediated endocytos

227 HgIA also required the adaptor protein-3 complex, which transports TLRs from th

228 moving processively towards minus ends in an adaptor protein-dependent manner.

229 This adaptor protein-mediated dynamic pump assembly allows th

230 via the appropriate receptors and the MyD88 adaptor protein.

231 terleukin-1 receptor (TIR) domain-containing adaptor protein.

232 f an enzyme target indirectly through a PilZ adaptor protein.

233 by the PDZ-protease Prc bound to its cognate adaptor protein.

234 ique mechanism that involves a discrete PilZ adaptor protein.

235 AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatiti

236 Adaptor proteins are a class of cytoplasmic proteins tha

237 es and forms inflammasome complexes with the adaptor proteins Asc and caspase-1 to promote the matura

238 During CME, endocytic adaptor proteins bind cargoes at the cell surface and li

239 Here the authors show that unique caspase adaptor proteins can regulate caspase activity within mu

240 owed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intr

241 receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to sti

242 The GIPC family adaptor proteins mediate endocytosis by tethering cargo

243 Here, we have found that the endocytic adaptor proteins NUMB and NUMBL were required for downre

244 Adaptor proteins such as receptor-interacting serine/thr

245 llular proteins are dimeric, multifunctional adaptor proteins that bind to and regulate the activitie

246 ytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of

247 facilitating the recruitment of cytoskeleton adaptor proteins to mediate pathogen uptake.

248 ce of an association of native neuronal AP-2 adaptor proteins with Slack channels, facilitated by a d

249 ification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular dom

250 molecular interactions among RNA molecules, adaptor proteins, and scaffold proteins.

251 riers by interaction of sorting signals with adaptor proteins, but proteins in the other domain exit

252 n of T cells (LAT) leading to recruitment of adaptor proteins, including Grb2, is one prototypical ex

253 nals in the cytosolic tails of the cargos by adaptor proteins, leading to cargo packaging into coated

254 aryotic cells which involves clathrin and/or adaptor proteins, lipid kinases, phosphatases and the ac

255 Upon ligand binding, TLRs and IL-1Rs recruit adaptor proteins, such as myeloid differentiation primar

256 cturally conserved between COPI and clathrin/adaptor proteins.

257 motifs could be a common mechanism for PilZ adaptor proteins.

258 s, cGAS, and IFI16 as well as their proximal adaptor proteins.

259 mplexes consisting of a class VII myosin and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and

260 with implications for the binding of certain adaptors, providing insight into how disease mutations l

261 AP-1 is a clathrin adaptor recruited to the trans-Golgi Network where it ca

262 TRAF1, a prosurvival signaling adaptor required for 4-1BB-mediated costimulation, is lo

263 Although the levels of the NOD2 adaptor, RIP2, are reported to regulate both acute and c

264 aptors must bind their cognate protease, all adaptors run the risk of being recognized by the proteas

265 p 1 Docs bound to Cohs of primary (ScaA) and adaptor (ScaB) scaffoldins were solved.

266 via a single-binding mode mechanism with an adaptor scaffoldin.

267 in and extra-terminal domain (BET) chromatin adaptors serve as immunomodulators by directly regulatin

268 hat represent the NB-ARC (nucleotide-binding adaptor shared by APAF-1, certain R gene products and CE

269 However, in contrast to the conventional Shc adaptors, ShcD suppresses distal phosphorylation of the

270 tivation of T cells (LAT) is a transmembrane adaptor signaling molecule that is part of the TCR compl

271 ODA16, a cargo adaptor specific for outer arm dynein, also fails to be

272 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dy

273 ng the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP) is the most freq

274 used by the Rod-Zw10-Zwilch complex and the adaptor Spindly to recruit dynein to kinetochores in Cae

275 e-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate cancers.

276 we show that depletion of the nuclear export adaptor SRSF1 prevents neurodegeneration and locomotor d

277 bacterial cell cycle and the quality control adaptor SspB.

278 equired the pattern recognition receptor and adaptor STING but not cGAS.

279 c GMP-AMP synthase (cGAS), the innate immune adaptor STING, and interferon signaling.

280 cient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3, or the type I IFN receptor IFNAR ex

281 nd messenger cGAMP to activate the signaling adaptor STING.

282 ability of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with artificial

283 PS) are redirected to autophagy via specific adaptors, such as p62.

284 d that this principle extends across several adaptor systems, including the hierarchical adaptors tha

285 ulfite (BS) conversion, preamplification and adaptor tagging, library amplification, sequencing and,

286 serve as a mitosis-specific minus-end cargo adaptor, targeting dynein activity to minus-ends to clus

287 Moreover, the use of an adaptor that links the two arms of the RNA duplex permit

288 2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT f

289 is an E3 ubiquitin ligase and a molecule of adaptor that we have shown is important for non-small-ce

290 zed myosin-binding proteins, putative myosin adaptors that belong to two unrelated families, with fou

291 adaptor systems, including the hierarchical adaptors that drive the Caulobacter bacterial cell cycle

292 hly controlled process involving proteolytic adaptors that regulate protein degradation during cell c

293 oly(rC)-binding proteins are multifunctional adaptors that serve as iron ion chaperones in the cytoso

294 o interact with the Toll-like receptor (TLR) adaptors TIRAP and MyD88, as well as the ubiquitin-assoc

295 of TNF receptor signaling, and serves as an adaptor to recruit other effectors.

296 y and a SOCS-box containing ubiquitin ligase adaptor to target GFP-tagged proteins for degradation.

297 We examine whether binding of cytoskeletal adaptors to integrin cytoplasmic domains is sufficient f

298 ts adaptor is adaptor substrate-specific, as adaptors with artificial degradation tags were not prote

299 Many adaptors work as scaffolds that selectively bind cargo a

300 ide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controll