ライフサイエンスコーパス: IRIS

1 inflammation (90% at diagnosis, 100% at PML-IRIS).

2 immune reconstitution inflammatory syndrome (IRIS).

3 of an immune recovery inflammatory syndrome (IRIS).

4 ne reconstitution inflammatory syndrome (PML-IRIS).

5 immune reconstitution inflammatory syndrome (IRIS).

6 ne reconstitution inflammatory syndrome (PML-IRIS).

7 lor parameter (higher value denoting lighter iris).

8 , 1.96-44.0]; P = .005) were predictive of C-IRIS.

9 ate immune system in the pathogenesis of TBM-IRIS.

10 were followed up until the occurrence of PML-IRIS.

11 sociated with increased risk of developing C-IRIS.

12 -alpha2 were associated with greater risk of IRIS.

13 enced, which is greatest in patients with TB-IRIS.

14 n a decline of CD8(+) T-cell responses after IRIS.

15 programmed using an intuitive web tool named Iris.

16 ssociated with development of paradoxical TB-IRIS.

17 some activation, was also elevated during TB-IRIS.

18 erse events in 3 patients with mycobacterial IRIS.

19 er implantation of the Ophtec 311 prosthetic iris.

20 nflammasome activity in myocardial and renal IRIs.

21 strategy for prevention and treatment of TB-IRIS.

22 ients with primary malignant melanoma of the iris.

23 baseline CD4 count <350 cells/muL developed IRIS.

24 umelanin, and non-pigmented areas within the iris.

25 loss of pigmentation in the skin, hair, and iris.

26 ing to the eye's ciliary body or even to the iris [20-22].

27 8/1059, 89%), ciliary body (85/1059, 8%), or iris (36/1059, 3%), with 19% being macular in location.

28 ociated with a 2.8-fold increased risk of TB-IRIS (95% confidence interval, 1.1 to 7.5-fold).

29 t in 2 cases JCV persisted > 21 months after IRIS accompanied by delayed clinical improvement.

30 cyclectomy for iris melanoma in 15 cases and iris adenoma in 1 case underwent prosthetic iris device

31 The sensitivity of the IRIS algorithm in detecting sight-threatening diabetic e

32 The IRIS algorithm population statistics were calculated.

33 sight-threatening diabetic eye disease, the IRIS algorithm positive predictive value was 10.8% (95%

34 The IRIS algorithm shows promise as a screening program, but

35 vels of cytokines and chemokines predicted C-IRIS and are potential predictive biomarkers.

36 of the retinal neuroepithelium that form the iris and ciliary body, thus correlating CPAMD8 expressio

37 s descended from surface ectoderm, while the iris and collagen-rich stroma of the cornea have a neura

38 tion defined by total or partial loss of the iris and leads to decreased visual quality marked by gla

39 T and OCTA images, qualitative evaluation of iris and tumor vasculature, and quantitative vessel dens

40 crosis factor blockade may be beneficial for IRIS and warrants further study in clinical trials.

41 immune reconstitution inflammatory syndrome (IRIS), and the side-effect profile.

42 The incidence of IRIS, and drug toxicity was not significantly different

43 genes incorporate into the lens, cornea and iris, and the eye placode is the sole source of retinal

44 Trabecular-iris angle (TIA) and angle opening distance 500 mum ante

45 iridocorneal angle measurements: trabecular-iris angle (TIA), angle opening distance (AOD500) and tr

46 Trabecular-iris angle (TIA), angle opening distance 500 mum from th

47 g exchangeable single-molecule localization (IRIS) approach to SMLM, in the context of the fibrous ac

48 The immunological mechanisms underlying C-IRIS are incompletely defined and no reliable predictive

49 ior chamber area (ACA), iris thickness (IT), iris area, iris curvature, lens vault (LV), anterior vau

50 ut there was no significant change in IT and iris area.

51 A 3D Robotics Iris+ autonomous quadrotor UAS was outfitted with a sens

52 (filament sign), arising from the peripheral iris (base of light bulb) and forming a tortuous loop on

53 (n = 1), before returning to the peripheral iris (base of light bulb).

54 The IRIS-based interpretations were compared with manual int

55 lular matrix turnover was associated with TB-IRIS, both before and during TB-IRIS onset.

56 immune reconstitution inflammatory syndrome (IRIS), but in 2 cases JCV persisted > 21 months after IR

57 immune reconstitution inflammatory syndrome (IRIS), but its underlying cause remains poorly understoo

58 tion of the PCIOL, and 1 patient experienced iris capture of the PCIOL after surgery.

59 Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4

60 f the anterior structures (anterior chamber, iris, ciliary body/muscle) was detected significantly mo

61 in the aqueous humor and the target tissue (iris-ciliary body) up to 24weeks.

62 rabecular-iris space area (TISA), trabecular-iris circumference volume (TICV), length of iridotrabecu

63 exchange with retropupillary fixation of an iris-claw IOL (n = 50).

64 The following data were obtained: Iris-claw IOL model, Iridal or retroiridal enclavation,

65 ants and formula for aphakia correction with iris-claw IOLs to achieve the best refractive status in

66 n = 54) or IOL exchange with a retropupillar iris-claw lens (n = 50).

67 E PRESENTATION: Two patients with a previous iris-claw PIOL implantation were enrolled.

68 e abnormalities in 8 eyes (47.1%), bilateral iris coloboma in 1 patient (2 eyes [11.8%]), and lens su

69 malformations, unicoronal craniosynostosis, iris colobomas, microphthalmia, and intestinal malrotati

70 Iris color was measured objectively, using the Commissio

71 Iris furrows and iris color were not associated with iris volume in light

72 on of flow signal in normal iris depended on iris color, with best penetration seen in light to moder

73 une reconstitution inflammatory syndrome (TB-IRIS) complicates combination antiretroviral therapy (cA

74 In this large urban setting, the IRIS computer algorithm-based screening program had a hi

75 Sensitivity and false-negative rate of the IRIS computer-based algorithm compared with reading cent

76 Trabecular-iris contact (TIC) was observed in 8 eyes of 8 subjects,

77 Patients with TB-IRIS were compared to non-IRIS controls using chi(2) and rank-sum tests and logist

78 tected in patients with TBM-IRIS than in non-IRIS controls.

79 ls/muL, were analyzed and compared to 94 non-IRIS controls.

80 tion revealed CPAMD8 expression in the lens, iris, cornea, and retina early in development, including

81 In light condition, higher iris crypt grade was associated independently with small

82 terior segment abnormalities included absent iris crypts, iris transillumination, lens subluxation, a

83 Iris curvature and LV were reduced (P = .01 for both) af

84 In both APAC eyes and fellow eyes, iris curvature decreased after LPI (P < .001).

85 The changes in angle parameters, ACA, and iris curvature were not significantly different between

86 and greater baseline anterior chamber depth, iris curvature, and lens vault (P </= 0.002 for all).

87 P children exhibited a narrower ACA, steeper iris curvature, and more anteriorly inserted iris than t

88 area (ACA), iris thickness (IT), iris area, iris curvature, lens vault (LV), anterior vault, angle o

89 ncrease in ACA was mainly owing to decreased iris curvature.

90 om EPA's Integrated Risk Information System (IRIS) database, Spearman rank correlation identified 68%

91 ed CENTRAL, CINAHL, Embase, MEDLINE, and WHO IRIS databases for publications between Jan 1, 2000, and

92 Sixteen patients (16 eyes) with iris defects after iridocyclectomy for iris melanoma in

93 n for the treatment of distinctive traumatic iris defects and results in an individual, aesthetically

94 Patients with iris defects suffer from severe visual impairment, espec

95 novative device in the surgical treatment of iris defects.

96 heterozygous null mutations showed no major iris defects.

97 Penetration of flow signal in normal iris depended on iris color, with best penetration seen

98 iris adenoma in 1 case underwent prosthetic iris device implantation surgery.

99 dual iris or opaque portions of a prosthetic iris device.

100 All iris devices were in the correct position, and all eyes

101 ariance ANOVA to investigate their impact on IRIS duration; and (3) a linear mixed model to assess th

102 ML presenting with lesions suggestive of PML-IRIS during follow-up.

103 azard ratio [HR] = 1.05; p = 0.92), but once IRIS emerged, its duration was significantly longer in p

104 Patients in whom TBM-IRIS eventually developed had significantly more abundan

105 anch molluscs Melibe leonina and Dendronotus iris exhibit homologous swimming behaviors, consisting o

106 ts without TB, and patients who developed TB-IRIS exhibited the greatest increase in casp1 expression

107 ) after the implantation of 2 types of rigid iris-fixated phakic intraocular lenses (pIOLs) for the t

108 ic (Ophtec B.V., Groningen, The Netherlands) iris-fixated pIOL for the treatment of myopia or astigma

109 rted after implantation with myopic or toric iris-fixated pIOLs.

110 In APAC eyes, the iris flattened, cACD deepened, and the lens shifted post

111 Iris freckles and the IPE cyst did not have intrinsic va

112 via the Intelligent Retinal Imaging System (IRIS) from June 2013 to April 2014 were included.

113 Iris furrows and iris color were not associated with iri

114 In a secondary analysis, patients with TB-IRIS had rapid, concomitant increases in tuberculosis-sp

115 The normal iris has radially oriented vessels within the stroma on

116 angiography performed in 1 eye depicted the iris hemangioma; however, small-caliber radial iris vess

117 Iris hypoplasia is likely to result from either complete

118 syndrome (GS) is characterized by bilateral iris hypoplasia, congenital hypotonia, non-progressive a

119 ared ocular manifestations include bilateral iris hypoplasia, ectopia lentis, corectopia, ectropion u

120 ebellar ataxia, intellectual disability, and iris hypoplasia.

121 ls, both of which could be associated with C-IRIS immunopathogenesis.

122 efore and after iris reconstruction with the iris implant placed in the ciliary sulcus.

123 Prosthetic iris implantation was combined with phacoemulsification

124 s, as does the inability to image the entire iris in a single field.

125 h, ACD, and ACA as well as flattening of the iris in APAC eyes.

126 xpression of ZIKV antigen was present in the iris in cases 1, 3, and 4; the neural retina and choroid

127 Immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-infected per

128 immune reconstitution inflammatory syndrome (IRIS) in natalizumab-associated progressive multifocal l

129 ) or an isotope ratio infrared spectrometer (IRIS) (in this case a Delta Ray (Thermo Fisher Scientifi

130 une reconstitution inflammatory syndrome (TB-IRIS), in Cape Town, South Africa.

131 d as the presence of anterior chamber seeds, iris infiltration, ciliary body/muscle infiltration, mas

132 d patients is increased before and during TB-IRIS, informing novel diagnostic strategies.

133 g in the American Academy of Ophthalmology's IRIS (Intelligent Research in Sight) Registry.

134 croscopic and microscopic composition of the iris is a contributing feature to angle-closure disease.

135 The implantation of the artificial iris is a new and effective therapeutic option for the t

136 immune reconstitution inflammatory syndrome (IRIS) is currently unclear.

137 reatment with PLEX was not associated to PML-IRIS latency (hazard ratio [HR] = 1.05; p = 0.92), but o

138 ng proST versus therST was not associated to IRIS latency (HR = 0.67; p = 0.39) or duration (p = 0.95

139 o investigate their impact on full-blown PML-IRIS latency; (2) an analysis of variance ANOVA to inves

140 report on an unusual case of a vascularized iris lesion in a three year old Caucasian patient, with

141 ignificantly expressed gene EPYC might cause iris lesion in MD.

142 When an iris lesion occurs in a pediatric patient, it can be dif

143 Patients with iris lesions and healthy volunteers.

144 ntify the best medical practice in pediatric iris lesions with atypical characteristics.

145 and 9 patients with iris melanomas or benign iris lesions, including freckles, nevi, and an iris pigm

146 OCTA) in malignant iris melanomas and benign iris lesions.

147 The iris-like channel opening is accompanied by an alpha-to-

148 etic to the channel were found to promote an iris-like conformational change that constricts and dehy

149 This analysis revealed that the iris-like expansion of the transmembrane helices mainly

150 - and agonist-bound states and determine the iris-like mechanism of ion channel opening.

151 rix nattereri) and opal-crowned (Lepidothrix iris) manakins of the Amazon basin, leading to the forma

152 This stability iris mechanism likely contributes to the narrowing of ra

153 or monitoring a variety of tumors, including iris melanocytic lesions, for growth and vascularity.

154 Referring diagnosis was iris melanoma (n = 1), infectious endotheliitis (n = 1),

155 To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 ((103)P

156 Five patients (n = 5/161 [3.1%]) with iris melanoma demonstrated local recurrence and 1 metast

157 One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers.

158 with iris defects after iridocyclectomy for iris melanoma in 15 cases and iris adenoma in 1 case und

159 ry in eyes with previous iridocyclectomy for iris melanoma or presumed iris melanoma.

160 A retrospective study was conducted for iris melanoma patients from 3 regional ophthalmologic ce

161 Iris melanoma patients treated with radiation therapy we

162 The most common findings related to iris melanoma regression after (103)Pd plaque brachyther

163 Patients undergoing iris melanoma resection are at risk of developing late s

164 Diffuse iris melanoma showed a higher risk of relapse (P = 0.044

165 aracteristics and outcomes for patients with iris melanoma using proton therapy.

166 dy and choroidal (CBC) melanoma and 160 with iris melanoma were evaluated.

167 Cancer, eighth edition, staging criteria for iris melanoma, 21 tumors (42%) were T1a, 5 tumors (10%)

168 ergone previous iridocyclectomy for presumed iris melanoma, combined cataract surgery and iris prosth

169 e extraocular relapse of previously resected iris melanoma, without concurrent intraocular recurrence

170 extraocular relapse from previously resected iris melanoma.

171 bconjunctival relapse of previously resected iris melanoma.

172 patients experienced metastases nor died of iris melanoma.

173 ridocyclectomy for iris melanoma or presumed iris melanoma.

174 ssel density was significantly higher within iris melanomas (34.5%+/-9.8%, P < 0.05) than in benign i

175 e tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions.

176 Iris melanomas demonstrated tortuous and disorganized in

177 h of 8 normal volunteers and 9 patients with iris melanomas or benign iris lesions, including freckle

178 apy showed efficacy and limited morbidity in iris melanomas.

179 ngioma course and its relation to the normal iris microvasculature.

180 ing progresses centrally in association with iris movement and aqueous flow.

181 filament) near the pupil (n = 3) or midzonal iris (n = 1), before returning to the peripheral iris (b

182 Patients with CM who experienced C-IRIS (N = 27) upon ART initiation were compared to CD4+

183 CD4+ T-cell count-matched patients without C-IRIS (N = 27).

184 EGF are elevated in patients with retinal or iris neovascularization, and VEGF-specific antagonists m

185 e were no reports of neovascular glaucoma or iris neovascularization.

186 pigmentation, and vascularity; incidence of iris neovascularization; and radiation-related complicat

187 omas (34.5%+/-9.8%, P < 0.05) than in benign iris nevi (8.0%+/-1.4%) or normal irides (8.0%+/-1.2%).

188 responses and development of paradoxical TB-IRIS on antiretroviral therapy (ART).

189 ated with TB-IRIS, both before and during TB-IRIS onset.

190 iris racemose hemangioma without associated iris or ciliary body solid tumor on clinical examination

191 were covered in all areas by either residual iris or opaque portions of a prosthetic iris device.

192 Among 3876 IRIS participants (mean age, 63 years; 65% male), 377 st

193 Of the 3876 IRIS participants, 3398 had a 3MS score at baseline and

194 The study cohort was composed of 3876 IRIS participants, mean age 63 years, 65% male, 89% whit

195 ary syndromes (MI and unstable angina) among IRIS participants.

196 nflammasome activation, are implicated in TB-IRIS pathogenesis.

197 bial translocation appear to be important in IRIS pathogenesis.

198 TB-IRIS patients also exhibited greater upregulation of NLR

199 TB-IRIS patients and controls had similar CD4 counts, level

200 n and T-cell subsets also were similar in TB-IRIS patients and controls.

201 ecrosis factor-alpha levels were higher in C-IRIS patients compared to controls (all P < .05), with I

202 asma mitochondrial DNA levels showed that TB-IRIS patients experienced greater cell death, especially

203 In contrast, TB-IRIS patients had significantly greater early increases

204 els were lower both pre- and post-cART in TB-IRIS patients, providing evidence of inadequate inflamma

205 CD4(+) T cells and NK cells was higher in TB-IRIS patients, providing evidence that IL-18 is a marker

206 ome activation both pre- and post-cART in TB-IRIS patients.

207 Digital iris photographs were taken from eyes of each participan

208 is lesions, including freckles, nevi, and an iris pigment epithelial (IPE) cyst, were imaged.

209 limitations in the characterization of human iris pigmentation, we introduce a fully automated approa

210 il recently, possible treatment options were iris print contact lenses, sunglasses, and simple iris p

211 to classify because of the wide spectrum of iris proliferations.

212 is difficult may consist of implantation of iris prostheses, devices designed to reduce symptoms of

213 print contact lenses, sunglasses, and simple iris prostheses.

214 The custom-made, flexible silicone iris prosthesis ArtificialIris (HumanOptics, Erlangen, G

215 functional results following implantation of iris prosthesis combined with cataract surgery in eyes w

216 ify in the context of traumatic aniridia and iris prosthesis implantation due to other potential etio

217 iris melanoma, combined cataract surgery and iris prosthesis placement, with or without iris reconstr

218 after more than 2 post-operative years, the iris prosthesis was explanted, and intravitreal cultures

219 on after implantation of this new artificial iris prosthesis.

220 as never been described in a patient with an iris prosthesis.

221 erative endophthalmitis in a patient with an iris prosthesis.

222 y angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the

223 Features of iris racemose hemangioma on OCTA.

224 Patients diagnosed with unilateral iris racemose hemangioma were included in the study.

225 Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study.

226 All eyes had sectoral iris racemose hemangioma without associated iris or cili

227 To describe OCTA features of iris racemose hemangioma.

228 y that clearly depicts the looping course of iris racemose hemangioma.

229 Patients were examined before and after iris reconstruction with the iris implant placed in the

230 d iris prosthesis placement, with or without iris reconstruction, can lead to visual improvement as w

231 Relating data from the IRIS Registry and NHANES could be a novel method for ass

232 IRIS Registry patients with nAMD who received bevacizuma

233 Data from the IRIS Registry were used to calculate the real-world prev

234 We analyzed data from the IRIS Registry, from January 1, 2012 to December 31, 2014

235 lmology (AAO) Intelligent Research in Sight (IRIS) Registry.

236 presence and effector pathway locally in the iris remain uncertain.

237 une reconstitution inflammatory syndrome (TB-IRIS) remains unclear.

238 r prophylactic use to prevent full-blown PML-IRIS seems to negatively impact on the longitudinal disa

239 e most common imaging sign suggestive of PML-IRIS, seen in 92.3% of the patients (with patchy and/or

240 ers angle opening distance (AOD), trabecular-iris space area (TISA), trabecular-iris circumference vo

241 gle opening distance (AOD500) and trabecular-iris space area (TISA500) 500 mum from the scleral spur,

242 ng distance (AOD500, AOD750), and trabecular iris space area (TISA500, TISA750) were measured in qual

243 m (AOD750) from the scleral spur; trabecular-iris space area at 500 mum (TISA500) and 750 mum (TISA75

244 anterior from scleral spur), the trabecular-iris-space area (TISA, measured 500 and 750 mum anterior

245 n the parasympathetic pathway activating the iris sphincter and ciliary muscle to mediate pupillary c

246 nopsin expression in a small subset of mouse iris sphincter muscle cells, with the light-induced cont

247 signals in the optic nerve ultimately drive iris-sphincter-muscle contraction via excitatory choline

248 (10%) at diagnosis, as compared with the PML-IRIS stage (40%).

249 at the time of PML diagnosis and at the PML-IRIS stage overlap but differ in their severity of infla

250 and folding translucent membrane behind the iris (stage 3), and a broad membrane within the pupil (s

251 s vessels against a background of low-signal iris stroma.

252 Iris stromal atrophy was noted in 26 patients (52%), pro

253 enlarged Soemmering ring provided posterior iris support in apposition to the anterior chamber angle

254 in AOD750, angle recess area, and trabecular iris surface area (P < 0.05 for all).

255 volume after pupil dilation with underlying iris surface features in right eyes were assessed using

256 age, 59.8+/-5.7 years) had gradable data for iris surface features.

257 Iris-sutured intraocular lenses have been used as an alt

258 17 eyes) who underwent placement of foldable iris-sutured PCIOLs between September 2004 and September

259 from before development of TBM-IRIS through IRIS symptom onset.

260 ation (LS) pupillary block (PB), and plateau iris syndrome (PL).

261 vent was adhesion between the cornea and the iris (synechia; n = 24).

262 In the case of the IRIS system, we demonstrate that the use of two standard

263 lammasomes was detected in patients with TBM-IRIS than in non-IRIS controls.

264 and significantly lower rates of relapse and IRIS than itraconazole.

265 iris curvature, and more anteriorly inserted iris than those of the full-term children (P < .001, P =

266 CA and a more anteriorly curved and inserted iris than those of the full-term children.

267 terferometric Reflectance Imaging Sensor (SP-IRIS) that allows multiplexed phenotyping and digital co

268 t of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) ha

269 medea, Tochuina tetraquetra, and Dendronotus iris, the number of GABA-ir neurons was highly consisten

270 er depth (ACD), anterior chamber area (ACA), iris thickness (IT), iris area, iris curvature, lens vau

271 Iris thickness was also measured.

272 transcripts, from before development of TBM-IRIS through IRIS symptom onset.

273 tics of inflammatory NTZ-PML lesions and PML-IRIS to determine differentiating and overlapping featur

274 Two patients with iris transillumination had glaucoma.

275 t abnormalities included absent iris crypts, iris transillumination, lens subluxation, and cataract.

276 The IRIS trial (Insulin Resistance Intervention after Stroke

277 The IRIS trial (Insulin Resistance Intervention after Stroke

278 nsulin Resistance Intervention after Stroke (IRIS) trial, patients with a recent ischaemic stroke or

279 1), and the initial finding by physician was iris tumor (n = 2) or hyphema (n = 1).

280 Our examination revealed solid iris tumor (n = 3), ciliary body involvement (n = 2), an

281 female patients and 1 male patient underwent iris tumor resection and presented to our service with s

282 This is the first demonstration of OCTA in iris tumors.

283 mune reconstitution inflammatory syndrome (C-IRIS), upon initiation of antiretroviral therapy (ART).

284 stics superimposed over small-caliber radial iris vessels against a background of low-signal iris str

285 is hemangioma; however, small-caliber radial iris vessels were more distinct on OCTA than intravenous

286 angiography depicted fine details of radial iris vessels, not distinct on intravenous fluorescein an

287 iris volume in light condition or change in iris volume (all P > 0.05).

288 de was associated independently with smaller iris volume (beta [change in iris volume in millimeters

289 Associations of the change in iris volume after pupil dilation with underlying iris su

290 rows and iris color were not associated with iris volume in light condition or change in iris volume

291 ly with smaller iris volume (beta [change in iris volume in millimeters per crypt grade increment] =

292 is volume on pupil dilation (beta [change in iris volume in millimeters per crypt grade increment] =

293 o -0.59; P = 0.001) and greater reduction of iris volume on pupil dilation (beta [change in iris volu

294 om semiautomated software, and the change in iris volume was quantified.

295 Iris volumes in light and dark conditions were measured

296 To investigate the pathogenesis of TBM-IRIS, we performed longitudinal whole-blood microarray a

297 tructures, and a hypoplastic or disorganized iris were also observed in the 3 cases.

298 Patients with TB-IRIS were compared to non-IRIS controls using chi(2) and

299 earliest sign of natalizumab-associated PML-IRIS with a frequent imaging pattern of contrast-enhanci

300 nosis was similar to the pattern seen at PML-IRIS, with contrast enhancement representing the most fr