Recently, the assosiation of rickets with prematurity has received attention because of the improved survival rates and increasing numbers of observations in very low-birth-weight (VLBW) infants. Vitamin D, calcium and phospholous deficiencies have been implicated as causative factors in these infants. During four-year period from September, 1980, we diagnosed rickets in seventeen of the sixty-six VLBW infants who had been hospitalized in the Neonatal Intensive Care Unit. Four had pathological fractures and one of them had the remnant deformity of bow legs. Usually most of the rickety VLBW infants are treated by the specialist of premature infants but in the case of having fracture or remnant deformity, orthopedic treatment and follow-up are needed.