高尾(東京都)産トリカブト塩基成分について

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タイトル別名
  • On the Alkaloids of Aconitum japonicum THUNB. collected at Mt. Takao (Tokyo)
  • タカオ トウキョウト サン トリカブト エンキ セイブン ニ ツイテ

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抄録

Reinvestigation of the alkaloidal constituents of Aconitum japonicum THUNB. of Mt. Takao (Tokyo) was made. In addition to the reported constituents, i.e. isohypognavine, delcosine and dehydrodelcosine, two known compounds, isotalatizidine and condelphine, were isolated. Furthermore, five new bases, i.e. 11-acetylisohypognavine, diacetylisohypognavine, 14-acetyltalatizamine, takaosamine and takaonine, were isolated and their structures were elucidated. Takaosamine was proved to be 18-O-demethyldelcosine from the spectroscopic study on the parent material and the acetyl derivatives, and from the chemical correlation with known diterpene alkaloids, gigactonine and delsoline. The structure of takaonine was deduced to be 2, 3-dehydro-14-dehydrodelcosine on the basis of 13C-nuclear magnetic resonance spectral evidence and the derivation to the known diterpene alkaloid, delcosine, by catalytic hydrogenation.

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  • 薬学雑誌

    薬学雑誌 99 (6), 647-656, 1979

    公益社団法人 日本薬学会

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