Cupid and Psyche system for the diagnosis and treatment of advanced cancer

Akira SUGIYAMA; Takeshi KAWAMURA; Toshiya TANAKA; Hirofumi DOI; Takefumi YAMASHITA; Keiko SHINODA; Hideaki FUJITANI; Kenzo YAMATSUGU; Yohei SHIMIZU; Toshifumi TATSUMI; Kazuki TAKAHASHI; Motomu KANAI; Eiichi MIZOHATA; Tatsuya KAWATO; Takefumi DOI; Tsuyoshi INOUE; Tatsuhiko KODAMA

doi:10.2183/pjab.95.041

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Cupid and Psyche system for the diagnosis and treatment of advanced cancer

Akira SUGIYAMA, Takeshi KAWAMURA, Toshiya TANAKA, Hirofumi DOI, Takefumi YAMASHITA, Keiko SHINODA, Hideaki FUJITANI, Kenzo YAMATSUGU, Yohei SHIMIZU, Toshifumi TATSUMI, Kazuki TAKAHASHI, Motomu KANAI, Eiichi MIZOHATA, Tatsuya KAWATO, Takefumi DOI, Tsuyoshi INOUE, Tatsuhiko KODAMA

Author information

Akira SUGIYAMA
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Isotope Science Center, The University of Tokyo
Takeshi KAWAMURA
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Isotope Science Center, The University of Tokyo
Toshiya TANAKA
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Hirofumi DOI
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Takefumi YAMASHITA
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Keiko SHINODA
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Hideaki FUJITANI
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
Kenzo YAMATSUGU
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Yohei SHIMIZU
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Toshifumi TATSUMI
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kazuki TAKAHASHI
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Motomu KANAI
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Eiichi MIZOHATA
Division of Applied Chemistry, Graduate School of Engineering, Osaka University
Tatsuya KAWATO
Division of Applied Chemistry, Graduate School of Engineering, Osaka University
Takefumi DOI
Graduate School and School of Pharmaceutical Sciences, Osaka University
Tsuyoshi INOUE
Graduate School and School of Pharmaceutical Sciences, Osaka University
Tatsuhiko KODAMA Corresponding author
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo

Keywords: cancer, monoclonal antibody, pre-targeting, photo-immunotherapy, theranostics

JOURNAL FREE ACCESS FULL-TEXT HTML

2019 Volume 95 Issue 10 Pages 602-611

DOI https://doi.org/10.2183/pjab.95.041

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Abstract

In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations, which makes radical cure very difficult. Precision medicine against advanced cancer is hampered by the lack of systems aimed at multiple target molecules within multiple loci. Here, we report the development of a versatile diagnostic and therapeutic system for advanced cancer, named the Cupid and Psyche system. Based on the strong non-covalent interaction of streptavidin and biotin, a low immunogenic mutated streptavidin, Cupid, and a modified artificial biotin, Psyche, have been designed. Cupid can be fused with various single-chain variable fragment antibodies and forms tetramer to recognize cancer cells precisely. Psyche can be conjugated to a wide range of diagnostic and therapeutic agents against malignant cells. The Cupid and Psyche system can be used in pre-targeting therapy as well as photo-immunotherapy effectively in animal models supporting the concept of a system for precision medicine for multiple targets within multiple loci.

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