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Pregnancy and Skin

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Abstract

Introduction

Skin changes occur in about 90 % pregnant women in one form or the other. The various skin changes maybe either physiological (hormonal), changes in pre-existing skin diseases or development of new pregnancy-specific dermatoses. All of these dermatoses can be attributed to the profound hormonal, vascular, metabolic, and immunological changes occurring during pregnancy.

Classification

Pregnancy-specific dermatoses have now been classified into dermatoses which are definitively associated and dermatoses with uncertain association with pregnancy. Though most of these skin dermatoses are benign and resolve in postpartum period, a few can risk fetal life and require antenatal surveillance. Most of the dermatoses of pregnancy can be treated conservatively but a few require intervention in the form of termination of pregnancy.

Conclusion

Careful history taking and examination will help us to identify each condition clinically and appropriate management can be instituted for the well-being of the mother and the fetus.

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References

  1. Kumari R, Jaisankar TJ, Thappa DM. A clinical study of skin changes in pregnancy. Indian J Dermatol Venereol Leprol. 2007;73(2):141.

    PubMed  Google Scholar 

  2. Wilder RL. Hormones, pregnancy, and autoimmune disease. Ann N Y Acad Sci. 1998;840:45–50.

    Article  PubMed  CAS  Google Scholar 

  3. Barankin B, Silver SG, Carruthers A. The skin in pregnancy. J Cutan Med Surg. 2002;6:236–40.

    Article  PubMed  Google Scholar 

  4. Chang AL, Agredano YZ, Kimball AB. Risk factors associated with striae gravidarum. J Am Acad Dermatol. 2004;51:881–5.

    Article  PubMed  Google Scholar 

  5. Gordon C. Pregnancy and autoimmune diseases. Best Pract Res Clin Rheumatol. 2004;18:359–79.

    PubMed  CAS  Google Scholar 

  6. Torgerson RR, Marnach ML, Bruce AJ. Oral and vulvar changes in pregnancy. Clin Dermatol. 2006;24:122–32.

    Article  PubMed  Google Scholar 

  7. Goldberg NS, DeFeo C, Kirshenbaum N. Pemphigus vulgaris and pregnancy: risk factors and recommendations. J Am Acad Dermatol. 1993;28:877–9.

    Article  PubMed  CAS  Google Scholar 

  8. Holmes RC, Black MM. The specific dermatoses of pregnancy. J Am Acad Dermatol. 1983;8:405–12.

    Article  PubMed  CAS  Google Scholar 

  9. Shornick JK. Dermatoses of pregnancy. Semin Cutan Med Surg. 1998;17:172–81.

    Article  PubMed  CAS  Google Scholar 

  10. Ambros-Rudolph CM, Mullegger RR, Vaughan-Jones SA, et al. The specific dermatoses of pregnancy revisited and reclassified: Results of a retrospective two-center study on 505 pregnant patients. Am Acad Dermatol. 2006;54:395–404.

    Article  Google Scholar 

  11. Sachdeva S. The dermatoses of pregnancy. Indian J Dermatol. 2008;53(3):103–5.

    Article  PubMed  Google Scholar 

  12. Shanmugam S, Thappa DM, Habeebullah S. Pruritus gravidarum: a clinical and laboratory study. J Dermatol. 1998;25(9):582–6.

    PubMed  CAS  Google Scholar 

  13. Black MM, McKay M, Braude PR. Color atlas and text of obstetric and gynecologic dermatology. 2nd ed. London: Times Mirror International Publishers Limited; 2001.

    Google Scholar 

  14. Sherard GB 3rd, Atkinson SM Jr. Focus on primary care: pruritic dermatological conditions in pregnancy. Obstet Gynecol Surv. 2001;56:427–32.

    Article  PubMed  Google Scholar 

  15. Varadi DP. Pruritus induced by crude bile and purified bile acids. Experimental production of pruritus in human skin. Arch Dermatol. 1974;109:678–81.

    Article  PubMed  CAS  Google Scholar 

  16. Winton GB, Lewis CW. Dermatoses of pregnancy. J Am Acad Dermatol. 1982;6:977–98.

    Article  PubMed  CAS  Google Scholar 

  17. Fagan EA. Intrahepatic cholestasis of pregnancy. BMJ. 1994;309:1243–4.

    Article  PubMed  CAS  Google Scholar 

  18. Hirvioja ML, Tuimala R, Vuori J. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. Br J Obstet Gynaecol. 1992;99:109–11.

    Article  PubMed  CAS  Google Scholar 

  19. Stephansson O, Granath F, Svensson T, et al. Drug use during pregnancy in Sweden—assessed by the Prescribed Drug Register and the Medical Birth Register. Clin Epidemiol. 2011;3:43–50.

    PubMed  Google Scholar 

  20. Seto A, Einarson T, Koren G. Pregnancy outcome following first trimester exposure to antihistamines: meta-analysis. Am J Perinatol. 1997;14:119–24.

    Article  PubMed  CAS  Google Scholar 

  21. Weber-Schoendorfer C, Schaefer C. The safety of cetirizine during pregnancy. A prospective observational cohort study. Reprod Toxicol. 2008;26:19–23.

    Article  PubMed  CAS  Google Scholar 

  22. Gilboa SM, Strickland MJ, Olshan AF, et al. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res A. 2009;85:137–50.

    Article  CAS  Google Scholar 

  23. Lis-Swiety AD, Brzezinska-Wcislo LA. The safety of the antihistamines in dermatoses of pregnancy. Wiad Lek. 2006;59:89–91.

    PubMed  Google Scholar 

  24. Kroumpouzos G, Cohen LM. Dermatoses of pregnancy. J Am Acad Dermatol. 2001;45(1–19):19–22.

    Google Scholar 

  25. Shornick JK, Black MM. Secondary autoimmune diseases in herpes gestationis (pemphigoid gestationis). J Am Acad Dermatol. 1992;26:563–6.

    Article  PubMed  CAS  Google Scholar 

  26. Al-Fares SI, Jones SV, Black MM. The specific dermatoses of pregnancy: a re-appraisal. J Eur Acad Dermatol Venereol. 2001;15:197–206.

    Article  PubMed  CAS  Google Scholar 

  27. Aronson IK, Bond S, Fiedler VC. Pruritic urticarial papules and plaques of pregnancy: clinical and immunopathologic observations in 57 patients. J Am Acad Dermatol. 1998;39:933–9.

    Article  PubMed  CAS  Google Scholar 

  28. Murray JC. Pregnancy and the skin. Dermatol Clin. 1990;8:327–34.

    PubMed  CAS  Google Scholar 

  29. Roger D, Vaillant L, Fignon A. Specific pruritic diseases of pregnancy. A prospective study of 3192 pregnant women. Arch Dermatol. 1994;130:734–9.

    Article  PubMed  CAS  Google Scholar 

  30. Black MM. Prurigo of pregnancy, papular dermatitis of pregnancy, and pruritic folliculitis of pregnancy. Semin Dermatol. 1989;8:23–5.

    PubMed  CAS  Google Scholar 

  31. Dahdah MJ, Kibbi AG. Less well-defined dermatoses of pregnancy. Clin Dermatol. 2006;24:118–21.

    Article  PubMed  Google Scholar 

  32. Vaughan Jones SA, Hern S, Nelson-Piercy C. A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles. Br J Dermatol. 1999;141:71–81.

    Article  PubMed  CAS  Google Scholar 

  33. Dacus JV. Pruritus in pregnancy. Clin Obstet Gynecol. 1990;33:738–45.

    Article  PubMed  CAS  Google Scholar 

  34. Bierman SM. Autoimmune progesterone dermatitis of pregnancy. Arch Dermatol. 1973;107:896–901.

    Article  PubMed  CAS  Google Scholar 

  35. Alcalay J, Ingber A, Hazaz B. Linear IgM dermatosis of pregnancy. J Am Acad Dermatol. 1988;18:412–5.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Venereology & Leprosy, Mahatma Gandhi Institute of Medical Sciences (MGIMS), Sevagram, Wardha, Maharashtra, 442012, India

    Sumit Kar (Professor and Head) & Ajay Krishnan (Assistant Professor)

  2. Department of Obstetrics and Gynaecology, Mahatma Gandhi Institute of Medical Sciences (MGIMS), Sevagram, Wardha, Maharashtra, 442012, India

    Poonam Varma Shivkumar (Professor)

Authors
  1. Sumit Kar
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  2. Ajay Krishnan
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  3. Poonam Varma Shivkumar
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Correspondence to Sumit Kar.

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Kar, S., Krishnan, A. & Shivkumar, P.V. Pregnancy and Skin. J Obstet Gynecol India 62, 268–275 (2012). https://doi.org/10.1007/s13224-012-0179-z

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