Extrachromosomal psi+ determinant suppresses nonsense mutations in yeast

J Bacteriol. 1979 Sep;139(3):1068-71. doi: 10.1128/jb.139.3.1068-1071.1979.

Abstract

The extrachromosomal psi+ determinant in the yeast Saccharomyces cerevisiae enhanced the expression of Mendelian UAA suppressors by 6- to 10-fold. The psi+ determinant by itself is a weak UAA suppressor that caused the production of approximately 1% of the normal level of iso-1-cytochrome c in a strain containing the UAA mutation cycl-72.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cytochrome c Group / analysis
  • Extrachromosomal Inheritance*
  • Mutation
  • Saccharomyces cerevisiae / genetics*
  • Species Specificity
  • Spectrophotometry
  • Suppression, Genetic*

Substances

  • Cytochrome c Group