INFLAMMATION AND FEVER

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© 1995 Academic Electronic Press
The publication is free to copy and distribute for non-commercial personal use with written permission of Academic Electronic Press. Any modifications of the original document are strictly prohibited. No fee is charged for using, copying or distributing. A written permission for distribution and copying can be obtained via Internet at the adress
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© 1995 Computing Centre, Slovak Academy of Sciences, Slovakia online
The book is also available in Internet. HTML format at URL =
http://www.savba.sk/logos/books/scientific/Inffever.html
ISBN 80--967366--1--2

Information on ''INFLAMMATION AND FEVER'':

Inflammation is a manifestation of the body's response to tissue damage and infection. The discovery of the detailed processes of inflammation has revealed a close relationship between inflammation and the immune response.

Inflammation is a complex stereotypical reaction involving a number of cellular and molecular components and important changes in the physiological systems as well. The result of each inflammatory reaction may be beneficial (defence the body against agents deranging its homeostasis) or harmful (damage to surrounding tissues). Therefore the basic information about this process is necessary for undergraduate and postgraduate students, clinicians, pathologists and other specialists in medicine, imunology, and molecular biology to whom the book is devoted.

It provides a short but comprehensive introduction to cellular and molecular aspects of exudation and sweling, cells participating in inflammation, mechanisms of their accumulation in inflamed tissue through the adhesive interaction between leukocytes and endothelial cells within the microcirculation, products of the complex plasma enzyme systems (the complement, kinin, haemocoagulation and fibrinolytic pathways), categories of inflammation mediated by the immune system and the role of fever.

The special chapters are focused on the regulatory functions of the adhesion molecules and inflammatory mediators, namely histamine and serotonin, bioactive lipids, proinflammatory and anti-inflammatory cytokines, chemotactic factors and the acute phase reactants. Regulation and control of body temperature and pathogenesis of fever are also discussed. Starting from the basic knowledges, the book offers survey of current concepts from both research and clinical points of view.
113 pages, 14 tables, 6 figures.

Published by:
Viera ’Stvrtinová, assistent professor of Internal Medicine,
Ján Jakubovský, associated professor of Pathology,
Ivan Hulín, professor of Pathophysiology
--- all in the Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

The book ''Inflammation and fever'' is available in Internet as:
1. PostScript file at URL = ftp://ftp.savba.sk/doc/books/Inffever.ps
2. HTML format at URL =
http://www.savba.sk/logos/books/scientific/Inffever.html

• Contents
• List of Figures
• List of Tables
• 1 Inflammation
  • 1.1 Principles of inflammation
    • 1.1.1 The response to injury and infection
    • 1.1.2 Factors involved in cell damage
    • 1.1.3 The phases of inflammation
  • 1.2 Exudation and swelling
    • 1.2.1 Fluid exudate
    • 1.2.2 Cellular exudate
  • 1.3 Cells participating in inflammation
    • 1.3.1 Mast cells and basophils
    • 1.3.2 Eosinophils
    • 1.3.3 Neutrophils, central cells in acute inflammation
      • 1.3.3.1 Neutrophil granules
      • 1.3.3.2 Neutrophils in host defence
      • 1.3.3.3 Neutrophils and host tissue damage
      • 1.3.3.4 Free radicals produced by neutrophils
      • 1.3.3.5 Regulation of neutrophil function
    • 1.3.4 Macrophages and monocytes
      • 1.3.4.1 Heterogeneity and activation of macrophages
      • 1.3.4.2 Biological functions of macrophages
      • 1.3.4.3 The role of macrophages in angiogenesis
  • 1.4 Mediators of inflammation
    • 1.4.1 Histamine and serotonin
    • 1.4.2 Lipid mediators
    • 1.4.3 Products of the complement system
    • 1.4.4 The coagulation mechanism
    • 1.4.5 Fibrinolysis
    • 1.4.6 The kinin-forming system
    • 1.4.7 Cytokines mediating inflammatory and effector functions
      • 1.4.7.1 Chemokines
    • 1.4.8 Chemotactic factors
    • 1.4.9 The acute phase reactants
  • 1.5 Molecular mechanisms of the acute cell-mediated inflammatory reaction
    • 1.5.1 Adhesion molecules
    • 1.5.2 Leukocyte mobility and chemotaxis
  • 1.6 Categories of inflammation mediated by the immune system
    • 1.6.1 Allergic (reaginic) acute inflammation
    • 1.6.2 Acute inflammation mediated by cytotoxic antibodies
    • 1.6.3 Acute inflammation mediated by immune complexes
    • 1.6.4 Chronic inflammation (delayed-type of hypersensitivity reaction)
• 2 Fever
  • 2.1 Regulation and control of body temperature
  • 2.2 Pathogenesis of fever
  • 2.3 Causes of fever
  • 2.4 Progress of the fever and accompanying symptoms
  • 2.5 Fever from the clinical point of view
• About this document ...