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serm

【仮名】serm
【原文】SERM

一部の組織ではエストロゲンと同様の作用を示すが、その他の組織ではエストロゲンの作用を阻害する薬物。タモキシフェンとラロキシフェンはsermである。「selective estrogen receptor modulator（選択的エストロゲン受容体調節薬）」とも呼ばれる。

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Serm

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選択的エストロゲン受容体修飾薬

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出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2023/07/12 15:00 UTC 版)

選択的エストロゲン受容体修飾薬（Selective estrogen receptor modulator；SERM）^[1]は、エストロゲン受容体作動薬/遮断薬（ERAA）^[2]としても知られ、エストロゲン受容体（ER）に作用する薬剤の一種である^[3]。これらの物質が純粋なER作動薬および遮断薬（即ち、完全作動薬および完全遮断薬）と異なる特徴は、その作用の強さが組織ごとにさまざまに異なるため、多種多様な組織でエストロゲン様作用を選択的に刺激または阻害する可能性があるということである。

注釈

^ この場合、A環が芳香化したステロイド骨格を指す。
^ 厳密には、CIP順位則に従い原子番号の大きな置換基から順番を付けるので、クロミフェンの場合はクロロ基とアミノエトキシフェニル基の位置関係で定まる。
^ アミノエトキシフェニル基を意味する。
^ アミノ基を含む側鎖のこと。

参考資料

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^ “Fablyn”. The European Medicines Agency (EMA). 2015年11月2日閲覧。

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Sermとは？ わかりやすく解説

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選択的エストロゲン受容体修飾薬

「Serm」の関連用語

Sermとは？わかりやすく解説