ハプトグロビン
出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2023/12/02 03:04 UTC 版)
ハプトグロビン(英: haptoglobin、略称: Hp)は、ヒトではHP遺伝子によってコードされるタンパク質である[5][6]。血漿中でハプトグロビンは赤血球から放出された遊離ヘモグロビンに高い親和性で結合し、その有害な酸化活性を阻害する[7]。一方類似した機能を持つヘモペキシンは遊離ヘムに対して結合する[8]。ハプトグロビン-ヘモグロビン複合体はその後、細網内皮系(主に脾臓)によって除去される。
- ^ a b c GRCh38: Ensembl release 89: ENSG00000257017 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031722 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Biological functions of haptoglobin--new pieces to an old puzzle”. European Journal of Clinical Chemistry and Clinical Biochemistry 35 (9): 647–54. (September 1997). PMID 9352226.
- ^ “Haptoglobin: function and polymorphism”. Clinical Laboratory 46 (11-12): 547–52. (2000). PMID 11109501.
- ^ a b c d “Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development”. Frontiers in Physiology (Frontiers Media SA) 5: 415. (2014-10-28). doi:10.3389/fphys.2014.00415. PMC 4211382. PMID 25389409 .
- ^ a b “Intravascular hemolysis”. eClinpath. 2019年5月8日閲覧。
- ^ “Entrez Gene: HP”. 2020年9月19日閲覧。
- ^ “Adipokines: inflammation and the pleiotropic role of white adipose tissue”. Br. J. Nutr. 92 (3): 347–55. (September 2004). doi:10.1079/BJN20041213. PMID 15469638.
- ^ “Bovine haptoglobin as an adipokine: Serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic acids supplement throughout lactation”. Vet Immunol Immunopathol 146 (3–4): 201–11. (May 2012). doi:10.1016/j.vetimm.2012.03.011. PMID 22498004.
- ^ Tamara, Sem; Franc, Vojtech; Heck, Albert J. R. (07 07, 2020). “A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin”. Proceedings of the National Academy of Sciences of the United States of America 117 (27): 15554–15564. doi:10.1073/pnas.2002483117. ISSN 1091-6490. PMC 7355005. PMID 32561649 .
- ^ “In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease”. Vasc Health Risk Manag 1 (1): 19–28. (2005). doi:10.2147/vhrm.1.1.19.58930. PMC 1993923. PMID 17319095 .
- ^ “Haptoglobin phenotypes in health and disorders”. Am. J. Clin. Pathol. 121 Suppl: S97–104. (June 2004). doi:10.1309/8GLX5798Y5XHQ0VW. PMID 15298155.
- ^ “Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in Hungarian patients”. Dig. Dis. Sci. 52 (5): 1279–84. (May 2007). doi:10.1007/s10620-006-9615-1. PMID 17357835.
- ^ “The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease”. American Journal of Medical Genetics 147B (2): 216–22. (March 2008). doi:10.1002/ajmg.b.30593. PMID 17918239.
- ^ “Iron metabolism and malaria”. Food Nutr Bull 28 (4 Suppl): S524–39. (December 2007). doi:10.1177/15648265070284S406. PMID 18297891.
- ^ Pintera J (1968). “The protective influence of haptoglobin on hemoglobinuric kidney. I. Biochemical and macroscopic observations”. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 90 (1): 82–91. PMID 4176393.
- ^ “[Pathogenesis of kidney hemolysis]” (German). Bruns Beitr Klin Chir 217 (7): 661–5. (December 1969). PMID 5404273.
- ^ Gene Overview of All Published Schizophrenia-Association Studies for HP Archived 21 February 2009 at the Wayback Machine. - SzGene database at Schizophrenia Research Forum.
- 1 ハプトグロビンとは
- 2 ハプトグロビンの概要
- 3 機能
- 4 合成
- 5 関連文献
- 6 関連項目
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