デンドリマーとは? わかりやすく解説

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デンドリマー

出典: フリー百科事典『ウィキペディア(Wikipedia)』 (2022/01/06 06:04 UTC 版)

デンドリマー (dendrimer) は、中心から規則的に分枝した構造を持つ樹状高分子[2][3]ギリシャ語で「木」を意味する デンドロン (δένδρον, dendron) から命名された。


  1. ^ Roland E. Bauer, Volker Enkelmann, Uwe M. Wiesler, Alexander J. Berresheim, Klaus Müllen (2002). “Single-Crystal Structures of Polyphenylene Dendrimers”. Chemistry: A European Journal英語版 8 (17): 3858. doi:10.1002/1521-3765(20020902)8:17<3858::AID-CHEM3858>3.0.CO;2-5. 
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  3. ^ Vögtle, Fritz / Richardt, Gabriele / Werner, Nicole Dendrimer Chemistry Concepts, Syntheses, Properties, Applications 2009 ISBN 3-527-32066-0
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  5. ^ Egon Buhleier, Winfried Wehner, Fritz Vögtle (1978). “"Cascade"- and "Nonskid-Chain-like" Syntheses of Molecular Cavity Topologies”. Synthesis 1978 (2): 155–158. doi:10.1055/s-1978-24702. 
  6. ^ アメリカ合衆国特許第4,289,872号 Denkewalter, Robert G., Kolc, Jaroslav, Lukasavage, William J.
  7. ^ アメリカ合衆国特許第4,410,688号
  8. ^ 吉村倫一. “特異な構造の両親媒性化合物が形成する会合体のナノ構造解析”. 2012年7月14日閲覧。
  9. ^ a b 青井啓悟ら (2003). “ナノ粒子としてのデンドリマー”. 高分子 52 (9): 682-686. 
  10. ^ アメリカ合衆国特許第4,507,466号
  11. ^ D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder and P. Smith (1985). “A New Class of Polymers: Starburst-Dendritic Macromolecules”. Polymer Journal 17: 117. doi:10.1295/polymj.17.117. 
  12. ^ “Treelike molecules branch out - chemist Donald A. Tomalia synthesized first dendrimer molecule - Chemistry - Brief Article”. Science News. (1996年). オリジナルの2012年7月8日時点におけるアーカイブ。. https://archive.is/20120708110929/http://findarticles.com/p/articles/mi_m1200/is_n2_v149/ai_17817461/ 
  13. ^ 榎修. “ナノ触媒を目指した精密金属集積高分子の創製”. 2012年7月14日閲覧。
  14. ^ a b George R. Newkome, Zhongqi Yao, Gregory R. Baker, Vinod K. Gupta (1985). “Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol”. J. Org. Chem. 50 (11): 2003. doi:10.1021/jo00211a052. 
  15. ^ Hawker, C. J.; Fréchet, J. M. J. (1990). “Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules”. J. Am. Chem. Soc. 112 (21): 7638. doi:10.1021/ja00177a027. 
  16. ^ 岡田鉦彦 (1998). “デンドリマー科学の新しい展開に向けて”. 高分子 47 (11): 803. 
  17. ^ a b c d e f 河野健司「デンドリマーのDDSへの応用」『Drug Delivery System』第17巻第6号、 470-。
  18. ^ Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications P. Antoni, Y. Hed, A. Nordberg, D. Nyström, H. von Holst, A. Hult and M. Malkoch Angew. Int. Ed., 2009, 48 (12), pp 2126-2130 doi:10.1002/anie.200804987 PMID 19117006
  19. ^ J. R. McElhanon and D. V. McGrath JOC, 2000, 65 (11), pp 3525-3529 doi:10.1021/jo000207a
  20. ^ C. O. Liang and J. M. J. Fréchet Macromolecules, 2005, 38 (15), pp 6276-6284 doi:10.1021/ma050818a
  21. ^ S. Hecht, J. M. J. Fréchet (2001). “Dendritic Encapsulation of Function: Applying Nature's Site Isolation Principle from Biomimetics to Materials Science”. Angew. Chem. Int. Ed. 40 (1): 74–91. doi:10.1002/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO;2-C. PMID 11169692. 
  22. ^ Frechet, Jean M.; Donald A. Tomalia (March 2002). Dendrimers and Other Dendritic Polymers. New York, NY: John Wiley & Sons. ISBN 978-0-471-63850-6 
  23. ^ M. Fischer, F. Vogtle (1999). “Dendrimers: From Design to Application—A Progress Report”. Angew. Chem. Int. Ed. 38 (7): 884. doi:10.1002/(SICI)1521-3773(19990401)38:7<884::AID-ANIE884>3.0.CO;2-K. 
  24. ^ a b c Holister, Paul; Christina Roman Vas, Tim Harper (2003年10月). “Dendrimers: Technology White Papers”. Cientifica. 2011年7月6日時点のオリジナル[リンク切れ]よりアーカイブ。2010年3月17日閲覧。
  25. ^ Polymer Factory AB, Stockholm, Sweden.Polymer Factory
  26. ^ Dendritech Inc., from Midland, Michigan, USA.Dendritech.
  27. ^ http://www.dnanotech.com
  28. ^ Hermanson, Greg T. (2008). “7”. Bioconjugate Techniques (2nd ed.). London: Academic Press of Elsevier. ISBN 978-0-12-370501-3 
  29. ^ Diels–Alder “Click” Chemistry in Designing Dendritic Macromolecules, Gregory Franc and Ashok K. Kakkar Chem. Eur. J. 2009 doi:10.1002/chem.200900252
  30. ^ Robust, Efficient, and Orthogonal Synthesis of Dendrimers via Thiol-ene “Click” Chemistry Kato L. Killops, Luis M. Campos and Craig J. Hawker J. Am. Chem. Soc., 2008, 130 (15), pp 5062–5064 doi:10.1021/ja8006325
  31. ^ Noda K, Minatogawa Y, Higuchi T (March 1991). “Effects of hippocampal neurotoxicant, trimethyltin, on corticosterone response to a swim stress and glucocorticoid binding capacity in the hippocampus in rats”. Jpn. J. Psychiatry Neurol. 45 (1): 107–8. PMID 1753450. 
  32. ^ Machaiah JP (May 1991). “Changes in macrophage membrane proteins in relation to protein deficiency in rats”. Indian J. Exp. Biol. 29 (5): 463–7. PMID 1916945. 
  33. ^ Dendrimer Design Using Cu(I)-Catalyzed Alkyne-Azide Click Chemistry, G. Franc, A. Kakkar Chem. Comm., 2008, pp 5267 - 5276 doi:10.1039/b809870k
  34. ^ Polyphenylene Dendrimers: From Three-Dimensional to Two-Dimensional Structures Angewandte Chemie International Edition in English Volume 36, Issue 6, Date: April 4, 1997, Pages: 631-634 Frank Morgenroth, Erik Reuther, Klaus Müllen doi:10.1002/anie.199706311
  35. ^ a b Morgan, Meredith T.; Yuka Nakanishi, David J. Kroll, Aaron P. Griset, Michael A. Carnahan, Michel Wathier, Nicholas H. Oberlies, Govindarajan Manikumar, Mansukh C. Wani and Mark W. Grinstaff (2006Meredith T. Morgan1). “Dendrimer-Encapsulated Camptothecins”. American Association for Cancer Research (1 Department of Chemistry, Duke University, 2 Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; 3 Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina; and 4 Departments of Biomedical Engineering and Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, Massachusetts) 66 (24): 11913–21. doi:10.1158/0008-5472.CAN-06-2066. PMID 17178889. 
  36. ^ Tekade, Rakesh Kumar; Tathagata Dutta, Virendra Gajbhiye and Narendra Kumar Jain (2009). “Exploring dendrimer towards dual drug delivery”. Journal of Microencapsulation英語版 (Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University,) 26 (4): 287–296. doi:10.1080/02652040802312572. PMID 18791906. 
  37. ^ Tathagata Dutta and N.K.Jain Targeting Potential and Anti HIV activity of mannosylated fifth generation poly (propyleneimine) Dendrimers. Biochimica et Biophysica Acta. 2007; 1770: 681-686.
  38. ^ Tathagata Dutta, Minakshi Garg, Narendra K. Jain. Targeting of Efavirenz Loaded Tuftsin Conjugated Poly(propyleneimine) dendrimers to HIV infected macrophages in vitro. Eur. J. Pharm. Sci. 2008.34(2-3):181-189.
  39. ^ Tathagata Dutta, Hrushikesh B. Agashe, Minakshi Garg, Prahlad Balakrishnan, Madhulika Kabra, & Narendra K. Jain. Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophages in vitro. Journal of Drug Targeting. 2007; 15(1): 84-96.
  40. ^ Cheng, Yiyun; Qinglin Wu, Yiwen Li, and Tongwen Xu (2008). “External Electrostatic Interaction versus Internal Encapsulation between Cationic Dendrimers and Negatively Charged Drugs: Which Contributes More to Solubility Enhancement of the Drugs?”. Journal of Physical Chemistry B (Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China) 112 (30): 8884–8890. doi:10.1021/jp801742t. PMID 18605754. 
  41. ^ Fu, Hui-Li; Si-Xue Cheng, Xian-Zheng Zhang, Ren-Xi Zhuo (2008). “Dendrimer/DNA complexes encapsulated functional biodegradable polymer for substrate-mediated gene delivery”. The Journal of Gene Medicine (Key Laboratory of Biomedical Polymers of Ministry of Education,Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China) 10 (12): 1334–1342. doi:10.1002/jgm.1258. PMID 18816481. 
  42. ^ Fu, HL; Cheng SX, Zhang XZ (2007). “Dendrimer/DNA complexes encapsulated in a water soluble polymer and supported on fast degrading star poly(DL-lactide) for localized gene delivery”. Journal of Control Release (Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University) 124 (3): 181–188.. doi:10.1016/j.jconrel.2007.08.031. PMID 17900738. 
  43. ^ Tathagata Dutta, Minakshi Garg, and N.K.Jain. Poly(propyleneimine) dendrimer and dendrosome based genetic immunization against Hepatitis B. Vaccine. 2008. 26(27-28): 3389-3394.
  44. ^ Fernandes, Edson G. R.; Vieira, Nirton C. S.; de Queiroz, Alvaro A. A.; Guimaraes, Francisco E. G.; Zucolotto, Valtencir. (2010). “Immobilization of Poly(propylene imine) Dendrimer/Nickel Phtalocyanine as Nanostructured Multilayer Films To Be Used as Gate Membranes for SEGFET pH Sensors”. Journal of Physical Chemistry C (American Chemical Society) 114 (14): 6478–6483. doi:10.1021/jp9106052. 
  45. ^ Campos, Bruno B; Algarra, Manuel; Esteves da Silva, Joaquim C. G (2010). “Fluorescent Properties of a Hybrid Cadmium Sulfide-Dendrimer Nanocomposite and its Quenching with Nitromethane”. Journal of Fluorescence (Springer) 20 (1): 143–151. doi:10.1007/s10895-009-0532-5. PMID 19728051. 
  46. ^ Grabchev, Ivo; Staneva, Desislava; Chovelon, Jean-Marc (2010). “Photophysical investigations on the sensor potential of novel, poly(propylenamine) dendrimers modified with 1,8-naphthalimide units”. Dyes and Pigments (Elsevier Ltd.,) 85 (3): 189–193. doi:10.1016/j.dyepig.2009.10.023. 
  47. ^ Twyman, Lance J.; Ge, Yi (2006). “Porphyrin cored hyperbranched polymers as heme protein models”. Chemical Communications (15): 1658. doi:10.1039/b600831n. ISSN 1359-7345. 
  48. ^ Twyman, Lance J.; Ellis, Adam; Gittins, Peter J. (2012). “Pyridine encapsulated hyperbranched polymers as mimetic models of haeme containing proteins, that also provide interesting and unusual porphyrin-ligand geometries”. Chem. Commun. 48 (1): 154–156. doi:10.1039/C1CC14396D. ISSN 1359-7345. 
  49. ^ 江東海 (1998). “デンドリマー・ハイパーブランチポリマーの機能”. 高分子 47 (11): 812-815. 
  50. ^ Crooks, Richard; Scott, Wilson (September 2005). “Synthesis, Characterization, and Applications of Dendrimer-Encapsulated Nanoparticles”. American Chemical Society (109): 692-704. 
  51. ^ a b 今栄東洋子 (1998). “機能する樹枝状高分子のハイブリッドとアーキテクチャー”. 高分子 47 (6): 415-419. 


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