ダプトマイシン
| 分子式： | C72H101N17O26 |
| その他の名称： | LY-146032、ダプトマイシン、Daptomycin、N-(N-Decanoyl-L-Trp-D-Asn-L-Asp-)cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-]、N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-]、N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-] |
| 体系名： | N-(N-デカノイル-L-Trp-D-Asn-L-Asp-)シクロ[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-メチル-L-Glu-]-3-(2-アミノベンゾイル)-L-Ala-]、N-[N-(1-オキソデシル)-L-Trp-D-Asn-L-Asp-]-シクロ[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-メチル-L-Glu-]-4-(2-アミノフェニル)-4-オキソ-L-Abu-]、N-[N-デカノイル-L-Trp-D-Asn-L-Asp-]-シクロ[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-メチル-L-Glu-]-3-(2-アミノベンゾイル)-L-Ala-] |
ダプトマイシン
ダプトマイシン
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2022/04/22 14:28 UTC 版)
ダプトマイシン(Daptomycin, DPT)はリポペプチド系の抗菌薬のひとつ。 ほとんどの抗菌薬が効かないMRSA感染による皮膚軟部組識感染や敗血症、感染性心内膜炎などの治療薬として利用される。
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- ^ Tally FP, DeBruin MF (October 2000). “Development of daptomycin for gram-positive infections”. J Antimicrob Chemother. 46 (4): 523–6. doi:10.1093/jac/46.4.523. PMID 11020247.
- ^ Charles PG, Grayson ML (November 2004). “The dearth of new antibiotic development: why we should be worried and what we can do about it”. Med J Aust. 181 (10): 549–53. PMID 15540967.
- ^ Template:日経メディカル 2011年7月31日
- ^ Pogliano J, Pogliano, N, Silverman, JA (September 2012). “Daptomycin-Mediated Reorganization of Membrane Architecture Causes Mislocalization of Essential Cell Division Proteins”. Journal of Bacteriology 194 (17): 4494–4504. doi:10.1128/JB.00011-12. PMID 22661688.
- ^ Daptomycin-Nonsusceptible Enterococcal Infections; Cleveland, Kerry O. MD; Gelfand, Michael S. MD; Infect Dis Clin Pract 2013;21: 79-84.
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- ^ Cubicin (daptomycin for injection) [homepage on the Internet].
- ^ “www.accessdata.fda.gov”. 2015年9月11日閲覧。
- ^ Daptomycin.
- ^ Journal of Antimicrobial Chemotherapy. 63(6):1299-300, 2009 Jun.
- ^ a b c d Nguyen KT, Kau D, Gu JQ (September 2006). “A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus”. Mol Microbiol. 61 (5): 1294–307. doi:10.1111/j.1365-2958.2006.05305.x. PMID 16879412.
- ^ Miao V, Coëffet-Legal MF, Brian P (May 2005). “Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry”. Microbiology (Reading, Engl.) 151 (Pt 5): 1507–23. doi:10.1099/mic.0.27757-0. PMID 15870461.
- ^ a b Steenbergen JN, Alder J, Thorne GM, Tally FP (March 2005). “Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections”. J Antimicrob. Chemother. 55 (3): 283–8. doi:10.1093/jac/dkh546. PMID 15705644.
- ^ a b Mchenney MA, Hosted TJ, Dehoff BS, Rosteck PR, Baltz RH (1 January 1998). “Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus”. J Bacteriol. 180 (1): 143–51. PMC 106860. PMID 9422604.
- ^ a b c d Fischbach MA, Walsh CT (August 2006). “Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms”. Chem Rev. 106 (8): 3468–96. doi:10.1021/cr0503097. PMID 16895337.
- ^ Baltz RH (February 1998). “Genetic manipulation of antibiotic-producing Streptomyces”. Trends Microbiol. 6 (2): 76–83. doi:10.1016/S0966-842X(97)01161-X. PMID 9507643.
- ^ a b c Baltz RH, Miao V, Wrigley SK (December 2005). “Natural products to drugs: daptomycin and related lipopeptide antibiotics”. Nat Prod Rep 22 (6): 717–41. doi:10.1039/b416648p. PMID 16311632.
- ^ a b c Baltz RH, Brian P, Miao V, Wrigley SK (February 2006). “Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus”. J Ind Microbiol Biotechnol. 33 (2): 66–74. doi:10.1007/s10295-005-0030-y. PMID 16193281.
- ^ Nguyen KT, Ritz D, Gu JQ (November 2006). “Combinatorial biosynthesis of novel antibiotics related to daptomycin”. Proc Natl Acad Sci USA. 103 (46): 17462–7. doi:10.1073/pnas.0608589103. PMC 1859951. PMID 17090667.
- ^ Kopp F, Grünewald J, Mahlert C, Marahiel MA (September 2006). “Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145”. Biochemistry 45 (35): 10474–81. doi:10.1021/bi0609422. PMID 16939199.
- ^ a b Miao V, Coëffet-Le Gal MF, Nguyen K (March 2006). “Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics”. Chem Biol. 13 (3): 269–76. doi:10.1016/j.chembiol.2005.12.012. PMID 16638532.
- ^ Baltz RH (December 2006). “Molecular engineering approaches to peptide, polyketide and other antibiotics”. Nat Biotechnol. 24 (12): 1533–40. doi:10.1038/nbt1265. PMID 17160059.
[続きの解説]
「ダプトマイシン」の続きの解説一覧
- 1 ダプトマイシンとは
- 2 ダプトマイシンの概要
- 3 歴史
- 4 Biosynthesis
- 5 脚注
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